President Donald Trump disseminated an AI-generated video on his Truth Social platform late Wednesday in which he appears as a physician diagnosing political opponents with “Trump Derangement Syndrome” and prescribing a treatment of Diet Coke, prayer, and turning off what he calls “fake news.” The 90-second clip, posted between official White House videos touting administration achievements, uses deepfake likenesses of actors and television hosts—including Whoopi Goldberg, Robert De Niro, Julia Roberts, Rosie O’Donnell, Edward Norton, and John Leguizamo—who are depicted as patients describing symptoms of distress before endorsing the purported cure.

Viewed from Washington, the video extends a pattern of AI-generated content the president has used to mock adversaries. US media reports note that a similar post in April, depicting Trump as Jesus Christ, was deleted after drawing criticism from Republican officials and triggering a diplomatic friction with the Vatican under Pope Leo XIV. Forbes and The Independent catalogue a series of such posts, including an image of Trump as a giant bearing the globe and another of him smoking a Cuban cigar, which have blurred the boundary between personal provocation and official communication. No formal White House statement has been issued on the latest video.

Russian state media described the clip as a “jocular treatment course” for the president’s critics, while Israeli and Arab outlets focused on the use of deepfake technology to parody prescription drug advertisements. Sky News Arabia traced the term “Trump Derangement Syndrome” to the earlier “Bush Derangement Syndrome,” coined by American commentator Charles Krauthammer in 2003 to describe acute paranoia triggered by the presidency of George W. Bush. Analysts in London note that the video’s prescription—Diet Coke, a product long associated with Trump’s personal brand—reinforces his conflation of political messaging with commercial and cultural symbolism.

The deployment of synthetic media by a sitting head of state raises legal and ethical questions about the non-consensual use of individuals’ likenesses, though no depicted celebrity has yet announced legal action. The video remains accessible on Truth Social, and the pattern of late-night AI posts suggests further such content is likely. The dossier remains open, with no indication of an official review or removal, and the White House has not commented on whether the video reflects an administration communication strategy.