
Younger generations show accelerated biological ageing, linked to early-onset cancers
A large study finds that people born after 1965 are ageing faster at the cellular level than earlier cohorts, while separate data reveal older Americans are living longer in better health, reshaping screening and retirement calculations.
People born in more recent decades are biologically older than their chronological age would suggest, and the gap is widening. Researchers at Washington University in St. Louis analysed blood markers from over 164,000 adults in the UK Biobank and the US All of Us programme, using epigenetic clocks to measure the pace of internal ageing. They found that British adults born between 1965 and 1974 showed 23% more accelerated ageing than those born between 1950 and 1954; in the US, the acceleration for the 1990–1999 cohort was 92% higher than for the 1965–1969 group. The study, published in Nature Medicine, then linked this faster biological ageing to a 15% higher risk of developing cancer before age 55, with the strongest associations for lung, gastrointestinal and uterine cancers. The work is observational and does not establish causation, but it points to lifestyle, environmental exposures and possibly immune-system ageing as contributors.
That finding sits in tension with another long-term trend. A working paper from the National Bureau of Economic Research, drawing on Medicare survey data from 1993 to 2017, shows that Americans at age 66 have gained 2.4 years of life expectancy, and those added years are spent entirely free of physical or cognitive limitations. Time spent in severe disability has shrunk by roughly 30%, reducing projected use of nursing homes and home-health aides. The authors, led by an MIT economist, describe this as delayed ageing rather than prolonged dying, and note that expected Medicare spending rose only 6%—far less than anticipated—because healthier older people require fewer interventions.
These biological patterns intersect with cultural and diagnostic realities. Men in particular are socialised to avoid help-seeking, a norm captured by the phrase “man up”. The World Health Organization data show men die younger in every region and are three to four times more likely to die by suicide in high-income countries. In Nigeria, where hypertension prevalence exceeds 34% and prostate cancer is the deadliest male malignancy, men make up a minority of outpatient visits; 80% of prostate cancers are diagnosed at an incurable stage. Meanwhile, the American Cancer Society has just updated its colorectal screening guidelines, endorsing new stool-based RNA and DNA tests that show high sensitivity for cancer and moderate sensitivity for advanced precancerous lesions. It recommends starting screening at 45 for average-risk individuals, while cautioning that blood-based tests are not yet reliable enough to replace stool tests or colonoscopy.
On the financial side, the shifting age profile is altering retirement arithmetic. The US Social Security Administration confirms that those born in 1956 who delay claiming beyond full retirement age receive an increased benefit, rising each month until age 70. For a narrow group—public-safety workers such as firefighters and police—the IRS “Rule of 55” allows penalty-free withdrawals from employer-sponsored 401(k) or 403(b) plans as early as age 50, provided they separate from service in that calendar year. Separately, older Americans carrying debt into retirement retain the option to file for bankruptcy; Social Security income is excluded from the Chapter 7 means test and is protected from seizure, though advisers caution that filing is most useful when non-exempt assets are at risk. The next milestones to watch are further research clarifying the drivers of accelerated ageing in younger cohorts and the gradual adoption of lower screening ages and novel stool tests in national programmes.
How the same story is told elsewhere.
2 editorial groups · 3 languages
Life expectancy in the U.S. has hit an all-time high, and health in old age is steadily improving. People are spending their final years with fewer physical limitations and better overall fitness than previous generations.
Scientists have found an unexpected reason for the surge in cancer among young people: younger generations are biologically aging faster than their parents. This accelerated aging is linked to a higher risk of early-onset cancer.
Related articles
Messi and Ronaldo trade historic blows as World Cup records tumble
13 languages · 93 outlets
Geopolitics & PoliticsUS Senate Joins House in Symbolic Rebuke of Trump’s Iran War, Passes War Powers Resolution
15 languages · 56 outlets
SportTrump to jointly present World Cup trophy at final, Infantino confirms
11 languages · 35 outlets